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The drugs of the first antihistamine generation are: promethazine, alimemazine, dexchlorpheniramine, brompheniramine, buclizine, carbinoxamine and doxylamine, are sedating and elicit a drowsiness which can be awkward.

Main outcome measure: Reporting of sedation or drowsiness.

Results: The odds ratios (adjusted for age and sex) for the incidence of sedation were 0.63 (95% confidence interval 0.36 to 1.11; P=0.1) for fexofenadine; 2.79 (1.69 to 4.58; P Antihistamines are often used to treat the symptoms of allergies such as seasonal and perennial allergic rhinitis and urticaria.

Fortunately, the child eventually recovered without any on-going ill-effects.

Sedating antihistamines have the ability to cross the blood-brain barrier, the ability to bind to non-histamine receptors and have less selectivity for peripheral or central H1-receptors.




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